Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance

Chengyan Chu, Anna Jablonska, Yue Gao, Xiaoyan Lan, Wojciech G. Lesniak, Yajie Liang, Guanshu Liu, Shen Li, Tim Magnus, Monica Pearl, Miroslaw Janowski, Piotr Walczak

Published: 2021-12-12 DOI: 10.1038/s41596-021-00634-x

Blood–brain barrier

Mannitol

Interventional MRI

Therapeutic delivery

Mouse model

AI 解读

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Heterogeneity（异质性）

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The blood–nobreakbrain barrier (BBB) is the main obstacle to the effective delivery of therapeutic agents to the brain, compromising treatment efficacy for a variety of neurological disorders. Intra-arterial (IA) injection of hyperosmotic mannitol
Introduction
Materials
Procedure
Troubleshooting
Timing
Anticipated results
References
ACKNOWLEDGMENTS

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Hyperosmolar blood–brain barrier opening using intra-arterial injection of hyperosmotic mannitol in mice under real-time MRI guidance

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